About 75% of all astronauts have taken medication during shuttle missions for conditions such as motion sickness, headache, sleeplessness, and back pain.
en.wikipedia.org As with caffeine, theobromine can cause sleeplessness, tremors, restlessness, anxiety, as well as contribute to increased production of urine.
en.wikipedia.org He was 94 years old and, when questioned concerning his claim of sleeplessness, maintained that he never actually dozed but merely rested.
en.wikipedia.org When used properly, and without the introduction of alcohol or other depressants, chloral hydrate is effective in easing sleeplessness due to pain or insomnia.
en.wikipedia.org Sufferers can exhibit several symptoms including hopelessness, a decrease in experiences of pleasure, constant stress and anxiety, sleeplessness or nightmares, and a pervasive negative attitude.
en.wikipedia.org