In addition to traumatic injuries, central chromatolysis may be caused by vitamin deficiency (pellagra).
en.wikipedia.org As early as 1755, pellagra was recognized by doctors as being a niacin deficiency disease.
en.wikipedia.org It also acts as an acid, chelating the vitamin niacin, the deficiency of which is known as pellagra.
en.wikipedia.org Common health problems included smallpox, diphtheria, typhoid, pellagra, tuberculosis and diabetes, with diagnosis depending on active symptoms, physical findings, and sputum examinations.
en.wikipedia.org Despite the presence of the "de novo" pathway, the salvage reactions are essential in humans; a lack of niacin in the diet causes the vitamin deficiency disease pellagra.
en.wikipedia.org