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They are a considered a virulence factor, facilitating the spread of gas gangrene.
en.wikipedia.org While in the armor, he goes insane due to the gangrene parasite inside the helmet and also becomes a wandering, murderous zombie.
en.wikipedia.org Eventually his leg is amputated by the headmistress, so as to avoid gangrene.
en.wikipedia.org His notes from the period express particular distress at wounds involving the knee-joint, and the regularity of gangrene-induced amputations.
en.wikipedia.org He remained in the game, but suffered from internal injuries that took his life two weeks later, when gangrene set in after three operations.
en.wikipedia.org